A Commensal Bacterium Promotes Virulence of an Opportunistic Pathogen via Cross-Respiration.

ABSTRACT:

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Bacteria rarely inhabit infection sites alone, instead residing in diverse, multispecies communities. Despite this fact, bacterial pathogenesis studies primarily focus on monoculture infections, overlooking how community interactions influence the course of disease. In this study, we used global mutant fitness profiling (transposon sequencing [Tn-seq]) to determine the genetic requirements for the pathogenic bacterium Aggregatibacter actinomycetemcomitans to cause disease when coinfecting with the commensal bacterium Streptococcus gordonii Our results show that S. gordonii extensively alters A. actinomycetemcomitans requirements for virulence factors and biosynthetic pathways during infection. In addition, we discovered that the presence of S. gordonii enhances the bioav

SUBMITTER: Stacy A 

PROVIDER: S-EPMC4916382 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature