Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study.

ABSTRACT:

Rationale

The indirect dopamine agonist methylphenidate remediates cognitive deficits in psychopathology, but the individual characteristics that determine its effects on the brain are not known.

Objectives

We aimed to determine whether targeted dopaminergically modulated traits and individual differences could predict neural response to methylphenidate across multiple functional magnetic resonance imaging (fMRI) procedures.

Methods

We combined neural measures from three separate procedures (two inhibitory control tasks differing in their degree of emotional salience and resting-state functional connectivity) during methylphenidate (20 mg oral, versus randomized and counterbalanced placebo) and correlated these aggregated responses with cocaine use disorder diagnosis

SUBMITTER: Moeller SJ 

PROVIDER: S-EPMC4916842 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature