Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations.

ABSTRACT:

Objective

 To estimate the potential magnitude in unselected patients of the benefits and harms of prolonged dual antiplatelet therapy after acute myocardial infarction seen in selected patients with high risk characteristics in trials.

Design

 Observational population based cohort study.

Setting

 PEGASUS-TIMI-54 trial population and CALIBER (ClinicAl research using LInked Bespoke studies and Electronic health Records).

Participants

 7238 patients who survived a year or more after acute myocardial infarction.

Interventions

 Prolonged dual antiplatelet therapy after acute myocardial infarction.

Main outcome measures

 Recurrent acute myocardial infarction, stroke, or fatal cardiovascular disease. Fatal, severe, or intracranial bleeding.

Results</

SUBMITTER: Timmis A 

PROVIDER: S-EPMC4916922 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature