Biodegradable Elastomers with Antioxidant and Retinoid-like Properties.

ABSTRACT: Intimal hyperplasia (IH) is a type of scarring that involves complex pathophysiological responses of the vasculature to injury, including overproliferation and migration of vascular smooth muscle cells (VSMCs), adventitial fibroblasts, and the activation of macrophages. The objective of this research was to develop a biodegradable polymer with intrinsic properties that would combat the cellular processes that contribute to IH. Citric acid, 1,8-octanediol, and all-trans retinoic acid (atRA) were incorporated into a polyester network via a condensation reaction to form the thermoset poly(1,8-octamethylene-citrate-co-retinate) (POCR). POCR was chemically characterized and assessed for the presence of antioxidant and retinoidlike properties. ^HNMR and ATR-FTIR confirmed the in

SUBMITTER: van Lith R 

PROVIDER: S-EPMC4916929 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature