Traditional and non-traditional risk factors for incident peripheral arterial disease among patients with chronic kidney disease.

ABSTRACT:

Background

The risk of peripheral arterial disease (PAD) is higher in patients with chronic kidney disease (CKD) compared with those without. However, reasons for this increased risk are not fully understood.

Methods

We studied risk factors for incident PAD among 3169 participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Patients with CKD aged 21-74 years were recruited between 2003 and 2008 and followed for a median of 6.3 years. Incident PAD was defined as a new onset ankle-brachial index (ABI) of <0.9 or confirmed clinical PAD.

Results

In a multivariate-adjusted model, older age, female sex, non-Hispanic Black, current smoking, diabetes, higher pulse pressure, lower high-density lipoprotein cholesterol, higher low-density lipoprotein cholesterol, and

SUBMITTER: Chen J 

PROVIDER: S-EPMC4917062 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature