Protective Effect of Dual-Strain Probiotics in Preterm Infants: A Multi-Center Time Series Analysis.

ABSTRACT:

Objective

To determine the effect of dual-strain probiotics on the development of necrotizing enterocolitis (NEC), mortality and nosocomial bloodstream infections (BSI) in preterm infants in German neonatal intensive care units (NICUs).

Design

A multi-center interrupted time series analysis.

Setting

44 German NICUs with routine use of dual-strain probiotics on neonatal ward level.

Patients

Preterm infants documented by NEO-KISS, the German surveillance system for nosocomial infections in preterm infants with birth weights below 1,500 g, between 2004 and 2014.

Intervention

Routine use of dual-strain probiotics containing Lactobacillus acidophilus and Bifidobacterium spp. (Infloran) on the neonatal ward level.

Main outcome measures

Incidences of NEC

SUBMITTER: Denkel LA 

PROVIDER: S-EPMC4917100 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature