Associations between Common Variants in Iron-Related Genes with Haematological Traits in Populations of African Ancestry.

ABSTRACT:

Background

Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African ancestry populations.

Methods

We tested the associations of 20 previously identified iron status-associated single nucleotide polymorphisms (SNPs) in 628 Kenyans, 609 Tanzanians, 608 South Africans and 228 African Americans. In each study, we examined the associations present between 20 SNPs with ferritin and haemoglobin, adjusting for age, sex and CRP levels.

Results

In the me

SUBMITTER: Gichohi-Wainaina WN 

PROVIDER: S-EPMC4917107 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature