Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.

ABSTRACT:

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Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity to change within individual liver cells, and that coordinate proliferative activity among different types of liver cells, are not well understood. Morphogenic signaling pathways that are active during fetal development, including Hedgehog and Hippo/Yes-associated protein 1 (Yap1), regulate liver regeneration in adulthood. Cirrhosis and liver cancer result when these pathways become dysregulated, but relatively little is known about the mechanisms that coordinate and control morphogenic signaling during effective liver regeneration. We evalu

SUBMITTER: Swiderska-Syn M 

PROVIDER: S-EPMC4917408 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature