Risk of hepatocellular carcinoma after sustained virological response in Veterans with hepatitis C virus infection.

ABSTRACT:

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The long-term prognosis in terms of risk or predictors of developing hepatocellular carcinoma (HCC) among patients with sustained virological response (SVR) remains unclear. We conducted a retrospective cohort study using data from the Veterans Affairs VA hepatitis C virus (HCV) Clinical Case Registry in patients with positive HCV RNA between October 1999 and August 2009 and follow-up through December 2010. HCV treatment (interferon with or without ribavirin) and SVR (RNA test negative at least 12 weeks after the end of treatment) were determined. We used Cox's proportional hazards models to calculate hazard ratios (HRs) for potential predictors (demographic, virological, and clinical) associated with HCC development post-SVR. We identified 33,005 HCV-infected individual

SUBMITTER: El-Serag HB 

PROVIDER: S-EPMC4917456 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature