Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy.

ABSTRACT: Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine (Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of cellular processes, including apoptosis and autophagy. The loss and gain-of-function of DAPK1 is associated with various cancer and neurodegenerative diseases respectively. In recent years, mechanistic studies have broadened our knowledge of the molecular mechanisms involved in DAPK1-mediated autophagy/apoptosis. In the present review, we have discussed the structural information and various cellular functions of DAPK1 in a comprehensive manner.

SUBMITTER: Singh P 

PROVIDER: S-EPMC4917528 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature