Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.

ABSTRACT:

Rationale

Lithium remains the most effective treatment for bipolar disorder and also has important effects to lower suicidal behaviour, a property that may be linked to its ability to diminish impulsive, aggressive behaviour. The antioxidant drug, ebselen, has been proposed as a possible lithium-mimetic based on its ability in animals to inhibit inositol monophosphatase (IMPase), an action which it shares with lithium.

Objectives

The aim of the study was to determine whether treatment with ebselen altered emotional processing and diminished measures of risk-taking behaviour.

Methods

We studied 20 healthy participants who were tested on two occasions receiving either ebselen (3600 mg over 24 h) or identical placebo in a double-blind, randomized, cross-over design. Thre

SUBMITTER: Masaki C 

PROVIDER: S-EPMC4917572 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature