Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma.

ABSTRACT:

Aim

To investigate the associiations between the polymorphisms of cell cycle pathway genes and the risk of hepatocellular carcinoma (HCC).

Methods

We enrolled 1127 cases newly diagnosed with HCC from the Tumor Hospital of Guangxi Medical University and 1200 non-tumor patients from the First Affiliated Hospital of Guangxi Medical University. General demographic characteristics, behavioral information, and hematological indices were collected by unified questionnaires. Genomic DNA was isolated from peripheral venous blood using Phenol-Chloroform. The genotyping was performed using the Sequenom MassARRAY iPLEX genotyping method. The association between genetic polymorphisms and risk of HCC was shown by P-value and the odd ratio (OR) with 95% confidence interval (CI) using the u

SUBMITTER: Nan YL 

PROVIDER: S-EPMC4917616 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature