Development of a population pharmacokinetic-pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients.

ABSTRACT:

Background

Unfractionated heparin (UFH) is the anticoagulant of choice in paediatric patients undergoing a variety of cardiac procedures. There are currently no population pharmacokinetic-pharmacodynamic (PKPD) models for UFH in paediatrics.

Objective

The aim of the present study was to develop and evaluate a PKPD model of UFH in paediatrics.

Methods

Data from 64 children who received 75-100 IU kg(-1) of UFH during cardiac angiography were analysed. Five blood samples were collected at baseline and at 15, 30, 45 and 120 min postdose. The UFH concentration was quantified using a protamine titration assay. The UFH effect was quantified using activated partial thromboplastin time (aPTT). A PKPD model was fitted using nonlinear mixed-effects modelling. Patient covariates

SUBMITTER: Al-Sallami H 

PROVIDER: S-EPMC4917811 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature