Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy.

ABSTRACT: The difficulty of controlling drug release at an intracellular level remains a key challenge for maximising drug safety and efficacy. We demonstrate herein a new, efficient and convenient approach to extracellularly control the intracellular release of doxorubicin (DOX), by designing a delivery system that harnesses the interactions between the system and a particular set of cellular machinery. By simply adding a small-molecule chemical into the cell medium, we could lower the release rate of DOX in the cytosol, and thereby increase its accumulation in the nuclei while decreasing its presence at mitochondria. Delivery of DOX with this system effectively prevented DOX-induced mitochondria damage that is the main mechanism of its toxicity, while exerting the maximum efficacy of this anti-can

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC4917837 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature