Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients.

ABSTRACT: The present study was to evaluate the diagnostic value of salivary total and oligomeric α-synuclein levels in PD. Furthermore, we sought to explore the relationship between salivary total α-synuclein and α-synuclein SNP variants levels. 201 PD patients and 67 controls were recruited, of which there also had the genetic information of two positive α-synuclein (SNCA) loci. Salivary total α-synuclein was assayed using a highly sensitive Luminex assay and oligomeric α-synuclein was quantified by the combination of Gel filtration chromatography and Western blot, respectively. From our analysis,No difference in salivary total α-synuclein levels was found between PD patients and healthy controls, it decreased with age in PD patients, and was closely associated with genotypic distribution of rs119

SUBMITTER: Kang W 

PROVIDER: S-EPMC4917865 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature