Genome-wide selective sweeps and gene-specific sweeps in natural bacterial populations.

ABSTRACT: Multiple models describe the formation and evolution of distinct microbial phylogenetic groups. These evolutionary models make different predictions regarding how adaptive alleles spread through populations and how genetic diversity is maintained. Processes predicted by competing evolutionary models, for example, genome-wide selective sweeps vs gene-specific sweeps, could be captured in natural populations using time-series metagenomics if the approach were applied over a sufficiently long time frame. Direct observations of either process would help resolve how distinct microbial groups evolve. Here, from a 9-year metagenomic study of a freshwater lake (2005-2013), we explore changes in single-nucleotide polymorphism (SNP) frequencies and patterns of gene gain and loss in 30 bacterial popu

SUBMITTER: Bendall ML 

PROVIDER: S-EPMC4918448 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature