Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population.

ABSTRACT:

Background

Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.

Objective

We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population.

Materials and methods

In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods.

Results

The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significan

SUBMITTER: Hassani M 

PROVIDER: S-EPMC4918774 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature