Mitochondrial function and glucose metabolism in the placenta with gestational diabetes mellitus: role of miR-143.

ABSTRACT: A predisposing factor for development of the hyperglycaemic state of gestational diabetes mellitus (GDM) is obesity. We previously showed that increasing maternal obesity is associated with significant reductions in placental mitochondrial respiration. MicroRNA (miR)-143 has been previously shown to regulate the metabolic switch from oxidative phosphorylation to aerobic glycolysis in cancer tissues. We hypothesized that mitochondrial respiration is reduced and aerobic glycolysis is up-regulated via changes in miR-143 expression in the placenta of women with GDM. Placental tissue was collected at term from women with A1GDM (controlled by diet), A2GDM (controlled by medication) and body mass index (BMI)-matched controls (CTRL). miR-143 expression was measured by RT-PCR. Expression of mitocho

SUBMITTER: Muralimanoharan S 

PROVIDER: S-EPMC4918818 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature