Antimalarial activity of a new family of analogues of manzamine A.

ABSTRACT: Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies. The synthesis and biological evaluation of a group of simplified analogues of manzamine A, which were designed to examine the roles of the A and D rings and of both the relative stereochemistry and the orientation of the beta-carboline heterocycle on the antimalarial activity of manzamine A, are described. [structure: see text]

SUBMITTER: Winkler JD 

PROVIDER: S-EPMC4918909 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature