Synthesis and biological evaluation of manzamine analogues.

ABSTRACT: [Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.

SUBMITTER: Winkler JD 

PROVIDER: S-EPMC4918913 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature