BDNF Expression in Larval and Adult Zebrafish Brain: Distribution and Cell Identification.

ABSTRACT: Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has emerged as an active mediator in many essential functions in the central nervous system of mammals. BDNF plays significant roles in neurogenesis, neuronal maturation and/or synaptic plasticity and is involved in cognitive functions such as learning and memory. Despite the vast literature present in mammals, studies devoted to BDNF in the brain of other animal models are scarse. Zebrafish is a teleost fish widely known for developmental genetic studies and is emerging as model for translational neuroscience research. In addition, its brain shows many sites of adult neurogenesis allowing higher regenerative properties after traumatic injuries. To add further knowledge on neurotrophic factors in vertebrate brai

SUBMITTER: Cacialli P 

PROVIDER: S-EPMC4918975 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature