Sleep Pathology in Creutzfeldt-Jakob Disease.

ABSTRACT:

Study objectives

Associations between sleep and neurodegenerative diseases have become increasingly evident. This study aims to characterize the prevalence and type of sleep pathology in Creutzfeldt-Jakob disease (CJD), a rapidly progressive, fatal neurodegenerative disease.

Methods

In this observational cross-sectional cohort study, we performed a retrospective analysis of sleep signs and symptoms in a consecutive group of patients with definite CJD at a tertiary care medical center (n = 28). Polysomnography was performed in 14 patients.

Results

Although only 5 of 28 patients carried a premorbid sleep diagnosis, signs/symptoms of sleep pathology were present in 25 patients. Eleven reported hypersomnia whereas 13 reported insomnia. Seven had restless legs symptoms and

SUBMITTER: Kang P 

PROVIDER: S-EPMC4918986 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature