Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification.

ABSTRACT:

Objective

Calcific aortic valve disease (CAVD) is the most prevalent type of heart valve disease, affecting ≈2% of the US population. CAVD is characterized by the presence of calcific nodules, resulting in aortic valve (AoV) stenosis; however, the underlying mechanisms driving disease remain unknown. Studies of human diseased AoV provide initial evidence that bone morphogenetic protein (BMP) signaling, essential for normal bone formation, is activated during CAVD. Mice deficient in Klotho, an FGF23 transmembrane coreceptor, exhibit premature aging and develop AoV calcific nodules as occurs in human CAVD. The role of BMP signaling in the development of CAVD was examined in porcine aortic valve interstitial cells (VICs) and Klotho(-/-) mice.

Approach and results

We show that a

SUBMITTER: Gomez-Stallons MV 

PROVIDER: S-EPMC4919184 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature