Parental rheumatoid arthritis and long-term child morbidity: a nationwide cohort study.

ABSTRACT:

Objective

To estimate the influence of parental rheumatoid arthritis (RA) on child morbidity.

Design

Nationwide cohort study.

Setting

Individual linkage to nationwide Danish registries.

Participants

All singletons born in Denmark during 1977-2008 (n=1 917 723) were followed for an average of 16 years.

Main outcome measures

Adjusted HRs for child morbidity; that is, 11 main diagnostic groups and specific autoimmune diseases within the International Classification of Diseases 8th and 10th versions.

Results

Compared with unexposed children, children exposed to maternal RA ('clinical' and 'preclinical') (n=13 566) had up to 26% higher morbidity in 8 of 11 main diagnostic groups. Similar tendencies were found in children exposed to paternal RA ('clinic

SUBMITTER: Rom AL 

PROVIDER: S-EPMC4919218 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature