Circulating microRNA-203 predicts prognosis and metastasis in human colorectal cancer.

ABSTRACT:

Background and aims

Distant metastasis is a major cause of deaths in patients with colorectal cancer (CRC), which is partly due to lack of robust metastasis-predictive biomarkers. In spite of the important function of microRNA (miR)-203 in cancer metastasis, its clinical significance in CRC metastasis remains unknown. Here, we evaluated the potential role of serum miR-203 as a non-invasive biomarker for CRC metastasis.

Methods

MiR-203 expression was quantified by quantitative reverse-transcription PCR in 58 pairs of primary CRC (pCRC) and corresponding matched liver metastasis (LM), as well as 186 serum and 154 matched tissue specimens from patients with CRC in cohort 1. Next, we performed validation of miR-203 levels in serum from 144 patients with CRC in an independent coh

SUBMITTER: Hur K 

PROVIDER: S-EPMC4919275 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature