Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.

ABSTRACT:

Background

Short-chain fatty acids (SCFAs), metabolites produced through the microbial fermentation of nondigestible dietary components, have key roles in energy homeostasis. Animal research suggests that colon-derived SCFAs modulate feeding behavior via central mechanisms. In humans, increased colonic production of the SCFA propionate acutely reduces energy intake. However, evidence of an effect of colonic propionate on the human brain or reward-based eating behavior is currently unavailable.

Objectives

We investigated the effect of increased colonic propionate production on brain anticipatory reward responses during food picture evaluation. We hypothesized that elevated colonic propionate would reduce both reward responses and ad libitum energy intake via stimulation of an

SUBMITTER: Byrne CS 

PROVIDER: S-EPMC4919527 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature