Ontology highlight
ABSTRACT:
SUBMITTER: Brinkman CC
PROVIDER: S-EPMC4919545 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nature communications 20160621
Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαβ rapidly modulates cytoskeletal and membrane structure of l ...[more]