Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model.

ABSTRACT: While many studies have shown that maternal weight and nutrition in pregnancy affects offspring's breast cancer risk, no studies have investigated the impact of paternal body weight on daughters' risk of this disease. Here, we show that diet-induced paternal overweight around the time of conception can epigenetically reprogram father's germ-line and modulate their daughters' birth weight and likelihood of developing breast cancer, using a mouse model. Increased body weight was associated with changes in the miRNA expression profile in paternal sperm. Daughters of overweight fathers had higher rates of carcinogen-induced mammary tumors which were associated with delayed mammary gland development and alterations in mammary miRNA expression. The hypoxia signaling pathway, targeted by miRNAs d

SUBMITTER: Fontelles CC 

PROVIDER: S-EPMC4919621 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature