Polyester type polyHIPE scaffolds with an interconnected porous structure for cartilage regeneration.

ABSTRACT: Development of artificial materials for the facilitation of cartilage regeneration remains an important challenge in orthopedic practice. Our study investigates the potential for neocartilage formation within a synthetic polyester scaffold based on the polymerization of high internal phase emulsions. The fabrication of polyHIPE polymer (PHP) was specifically tailored to produce a highly porous (85%) structure with the primary pore size in the range of 50-170 μm for cartilage tissue engineering. The resulting PHP scaffold was proven biocompatible with human articular chondrocytes and viable cells were observed within the materials as evaluated using the Live/Dead assay and histological analysis. Chondrocytes with round nuclei were organized into multicellular layers on the PHP surface and w

SUBMITTER: Naranda J 

PROVIDER: S-EPMC4919626 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature