Gut Bacteria Metabolism Impacts Immune Recovery in HIV-infected Individuals.

ABSTRACT: While changes in gut microbial populations have been described in human immuno-deficiency virus (HIV)-infected patients undergoing antiretroviral therapy (ART), the mechanisms underlying the contributions of gut bacteria and their molecular agents (metabolites and proteins) to immune recovery remain unexplored. To study this, we examined the active fraction of the gut microbiome, through examining protein synthesis and accumulation of metabolites inside gut bacteria and in the bloodstream, in 8 healthy controls and 29 HIV-infected individuals (6 being longitudinally studied). We found that HIV infection is associated to dramatic changes in the active set of gut bacteria simultaneously altering the metabolic outcomes. Effects were accentuated among immunological ART responders, regardless d

SUBMITTER: Serrano-Villar S 

PROVIDER: S-EPMC4919658 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature