Chronic Kidney Disease, Time in Therapeutic Range and Adverse Clinical Outcomes in Anticoagulated Patients with Non-valvular Atrial Fibrillation: Observations from the SPORTIF Trials.

ABSTRACT:

Background

Chronic kidney disease (CKD) is highly prevalent in atrial fibrillation (AF) patients and associated with an increased risk of adverse outcomes. Our objectives were to study clinical features associated with CKD in AF patients and the impact of CKD on anticoagulation control, as reflected by time in therapeutic range (TTR). We also determined the impact of CKD and TTR in predicting adverse outcomes.

Methods and results

We analysed pooled datasets from SPORTIF III and V trials, including 3646 patients assigned to warfarin with data on renal function. CKD (creatinine clearance <60ml/min) was present in 952 (26%) patients. TTR was higher in patients with normal renal function compared to those with CKD (p<0.001). On logistic analysis, chronic AF and male sex were ass

SUBMITTER: Proietti M 

PROVIDER: S-EPMC4919727 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature