Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling.

ABSTRACT: The coagulation cascade is designed to sense tissue injury by physical separation of the membrane-anchored cofactor tissue factor (TF) from inactive precursors of coagulation proteases circulating in plasma. Once TF on epithelial and other extravascular cells is exposed to plasma, sequential activation of coagulation proteases coordinates hemostasis and contributes to host defense and tissue repair. Membrane-anchored serine proteases (MASPs) play critical roles in the development and homeostasis of epithelial barrier tissues; how MASPs are activated in mature epithelia is unknown. We here report that proteases of the extrinsic pathway of blood coagulation transactivate the MASP matriptase, thus connecting coagulation initiation to epithelial proteolysis and signaling. Exposure of TF-expres

SUBMITTER: Le Gall SM 

PROVIDER: S-EPMC4920024 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature