Conditioning adaptive combination of P-values method to analyze case-parent trios with or without population controls.

ABSTRACT: Detection of rare causal variants can help uncover the etiology of complex diseases. Recruiting case-parent trios is a popular study design in family-based studies. If researchers can obtain data from population controls, utilizing them in trio analyses can improve the power of methods. The transmission disequilibrium test (TDT) is a well-known method to analyze case-parent trio data. It has been extended to rare-variant association testing (abbreviated as "rvTDT"), with the flexibility to incorporate population controls. The rvTDT method is robust to population stratification. However, power loss may occur in the conditioning process. Here we propose a "conditioning adaptive combination of P-values method" (abbreviated as "conADA"), to analyze trios with/without unrelated controls. By fir

SUBMITTER: Lin WY 

PROVIDER: S-EPMC4920030 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature