Bone structure and function in male C57BL/6 mice: Effects of a high-fat Western-style diet with or without trace minerals.

ABSTRACT:

Purpose

Osteoporosis occurs in both women and men, but most of what we know about the condition comes from studies in females. The present study examined bone structure and function over an 18-month period in male C57BL/6 mice maintained on either a rodent chow diet (AIN76A) or a high-fat, Western-style diet (HFWD). Effects of mineral supplementation were assessed in both diets.

Methods

Trabecular and cortical bone structure in femora and vertebrae were assessed by micro-CT analysis. Following this, bone stiffness and strength measurements were made. Finally, bone levels of several cationic trace elements were quantified, and serum biomarkers of bone metabolism evaluated.

Results

Bone loss occurred over time in both diets but was more rapid and extensive in mice on th

SUBMITTER: Aslam MN 

PROVIDER: S-EPMC4920365 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature