Extensive Transcriptomic and Genomic Analysis Provides New Insights about Luminal Breast Cancers.

ABSTRACT: Despite constituting approximately two thirds of all breast cancers, the luminal A and B tumours are poorly classified at both clinical and molecular levels. There are contradictory reports on the nature of these subtypes: some define them as intrinsic entities, others as a continuum. With the aim of addressing these uncertainties and identifying molecular signatures of patients at risk, we conducted a comprehensive transcriptomic and genomic analysis of 2,425 luminal breast cancer samples. Our results indicate that the separation between the molecular luminal A and B subtypes-per definition-is not associated with intrinsic characteristics evident in the differentiation between other subtypes. Moreover, t-SNE and MST-kNN clustering approaches based on 10,000 probes, associated with luminal

SUBMITTER: Tishchenko I 

PROVIDER: S-EPMC4920434 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature