Patients With Coronary Endothelial Dysfunction Have Impaired Cholesterol Efflux Capacity and Reduced HDL Particle Concentration.

ABSTRACT:

Rationale

Coronary endothelial dysfunction (ED)-an early marker of atherosclerosis-increases the risk of cardiovascular events.

Objective

We tested the hypothesis that cholesterol efflux capacity and high-density lipoprotein (HDL) particle concentration predict coronary ED better than HDL-cholesterol (HDL-C).

Methods and results

We studied 80 subjects with nonobstructive (<30% stenosis) coronary artery disease. ED was defined as <50% change in coronary blood flow in response to intracoronary infusions of acetylcholine during diagnostic coronary angiography. Cholesterol efflux capacity and HDL particle concentration (HDL-PIMA) were assessed with validated assays. Cholesterol efflux capacity and HDL-PIMA were both strong, inverse predictors of ED (P<0.001 and 0.005, res

SUBMITTER: Monette JS 

PROVIDER: S-EPMC4920704 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature