Role of Indole Production on Virulence of Vibrio cholerae Using Galleria mellonella Larvae Model.

ABSTRACT: Cell to cell communication facilitated by chemical signals plays crucial roles in regulating various cellular functions in bacteria. Indole, one such signaling molecule has been demonstrated to control various bacterial phenotypes such as biofilm formation and virulence in diverse bacteria including Vibrio cholerae. The present study explores some key factors involved in indole production and the subsequent pathogenesis of V. cholerae. Indole production was higher at 37 °C than at 30 °C, although the growth at 37 °C was slightly higher. A positive correlation was observed between indole production and biofilm formation in V. cholerae. Maximum indole production was detected at pH 7. There was no significant difference in indole production between clinical and environmental V. cholerae isola

SUBMITTER: Nuidate T 

PROVIDER: S-EPMC4920769 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature