Newcastle disease virus-vectored West Nile fever vaccine is immunogenic in mammals and poultry.

ABSTRACT:

Background

West Nile virus (WNV) is an emerging zoonotic pathogen which is harmful to human and animal health. Effective vaccination in susceptible hosts should protect against WNV infection and significantly reduce viral transmission between animals and from animals to humans. A versatile vaccine suitable for different species that can be delivered via flexible routes remains an essential unmet medical need. In this study, we developed a recombinant avirulent Newcastle disease virus (NDV) LaSota strain expressing WNV premembrane/envelope (PrM/E) proteins (designated rLa-WNV-PrM/E) and evaluated its immunogenicity in mice, horses, chickens, ducks and geese.

Results

Mouse immunization experiments disclosed that rLa-WNV-PrM/E induces significant levels of WNV-neutralizing anti

SUBMITTER: Wang J 

PROVIDER: S-EPMC4920995 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature