Rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda.

ABSTRACT:

Objective

To determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda.

Design

A retrospective analysis of individuals who participated in a clinical cohort study among high-risk FSWs in Kampala, Uganda.

Methods

Plasma samples from HIV-infected FSWs in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41 HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSWs from the same cohort, and incidence rate ratios were compared.

Results

The rate of superinfection in these women (7/85; 3.4/100 person-years) was not significantly different from the rate of primary infection in the same popul

SUBMITTER: Redd AD 

PROVIDER: S-EPMC4921228 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature