Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults.

ABSTRACT:

Background

Even among ostensibly healthy adults, there is often mild pathology in the kidney. The detection of kidney microstructural variation and pathology by imaging and the clinical pattern associated with these structural findings is unclear.

Study design

Cross-sectional (clinical-pathologic correlation).

Setting & participants

Living kidney donors at Mayo Clinic (Minnesota and Arizona sites) and Cleveland Clinic 2000 to 2011.

Predictors

Predonation kidney function, risk factors, and contrast computed tomographic scan of the kidneys. These scans were segmented for cortical volume and medullary volume, reviewed for parenchymal cysts, and scored for kidney surface roughness.

Outcomes

Nephrosclerosis (glomerulosclerosis, interstitial fibrosis/tubular a

SUBMITTER: Denic A 

PROVIDER: S-EPMC4921258 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature