Office-based olfactory mucosa biopsies.

ABSTRACT:

Background

Requests from researchers for olfactory mucosal biopsies are increasing as a result of advances in the fields of neuroscience and stem cell biology. Published studies report variable rates of success in obtaining true olfactory tissue, often below 50%. In cases where biopsies are not obtained carefully and confirmed through histological techniques, erroneous conclusions are made. Attention to the epithelium alone without submucosal analysis may add to the confusion. A consistent biopsy technique can help rhinologists obtain higher yields of olfactory mucosa. Confirmatory tissue staining analysis assures olfactory mucosa has been obtained, thereby strengthening clinical correlations and scientific conclusions.

Methods

Biopsies of the septum within the anterior olfa

SUBMITTER: Holbrook EH 

PROVIDER: S-EPMC4921276 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature