The RNA 3D Motif Atlas: Computational methods for extraction, organization and evaluation of RNA motifs.

ABSTRACT: RNA 3D motifs occupy places in structured RNA molecules that correspond to the hairpin, internal and multi-helix junction "loops" of their secondary structure representations. As many as 40% of the nucleotides of an RNA molecule can belong to these structural elements, which are distinct from the regular double helical regions formed by contiguous AU, GC, and GU Watson-Crick basepairs. With the large number of atomic- or near atomic-resolution 3D structures appearing in a steady stream in the PDB/NDB structure databases, the automated identification, extraction, comparison, clustering and visualization of these structural elements presents an opportunity to enhance RNA science. Three broad applications are: (1) identification of modular, autonomous structural units for RNA nanotechnology,

SUBMITTER: Parlea LG 

PROVIDER: S-EPMC4921307 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature