Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation.

ABSTRACT:

Objective

Insulin signaling plays pivotal roles in the development and metabolism of many tissues and cell types. A previous study demonstrated that ablation of insulin receptor (IR) with aP2-Cre markedly reduced adipose tissues mass and protected mice from obesity. However, multiple studies have demonstrated widespread non-adipocyte recombination of floxed alleles in aP2-Cre mice. These findings underscore the need to re-evaluate the role of IR in adipocyte and systemic metabolism with a more adipose tissue-specific Cre mouse line.

Methods

We generated and phenotyped a new adipose tissue-specific IR mouse model using the adipose tissue-specific Adipoq-Cre line.

Results

Here we show that the Adipoq-Cre-mediated IR KO in mice leads to lipodystrophy and metabolic dysfun

SUBMITTER: Qiang G 

PROVIDER: S-EPMC4921803 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature