Three-dimensional bioprinting using self-assembling scalable scaffold-free "tissue strands" as a new bioink.

ABSTRACT: Recent advances in bioprinting have granted tissue engineers the ability to assemble biomaterials, cells, and signaling molecules into anatomically relevant functional tissues or organ parts. Scaffold-free fabrication has recently attracted a great deal of interest due to the ability to recapitulate tissue biology by using self-assembly, which mimics the embryonic development process. Despite several attempts, bioprinting of scale-up tissues at clinically-relevant dimensions with closely recapitulated tissue biology and functionality is still a major roadblock. Here, we fabricate and engineer scaffold-free scalable tissue strands as a novel bioink material for robotic-assisted bioprinting technologies. Compare to 400 μm-thick tissue spheroids bioprinted in a liquid delivery medium into con

SUBMITTER: Yu Y 

PROVIDER: S-EPMC4921918 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature