STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation.

ABSTRACT: Although a close connection between uterine regeneration and successful pregnancy in both humans and mice has been consistently observed, its molecular basis remains unclear. We here established a mouse model of decellularized uterine matrix (DUM) transplantation. Resected mouse uteri were processed with SDS to make DUMs without any intact cells. DUMs were transplanted into the mouse uteri with artificially induced defects, and all the uterine layers were recovered at the DUM transplantation sites within a month. In the regenerated uteri, normal hormone responsiveness in early pregnancy was observed, suggesting the regeneration of functional uteri. Uterine epithelial cells rapidly migrated and formed a normal uterine epithelial layer within a week, indicating a robust epithelial-regenerati

SUBMITTER: Hiraoka T 

PROVIDER: S-EPMC4922514 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature