The Schistosomiasis Clinical Trials Landscape: A Systematic Review of Antischistosomal Treatment Efficacy Studies and a Case for Sharing Individual Participant-Level Data (IPD).

ABSTRACT:

Background

Schistosomiasis control mainly relies on preventive chemotherapy with praziquantel (PZQ) distributed through mass drug administration. With a target of 260 million treatments yearly, reliably assessing and monitoring efficacy is all-important. Recommendations for treatment and control of schistosomiasis are supported by systematic reviews and meta-analyses of aggregated data, which however also point to limitations due to heterogeneity in trial design, analyses and reporting. Some such limitations could be corrected through access to individual participant-level data (IPD), which facilitates standardised analyses.

Methodology

A systematic literature review was conducted to identify antischistosomal drug efficacy studies performed since 2000; including electronic s

SUBMITTER: Jule AM 

PROVIDER: S-EPMC4922574 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature