Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients.

ABSTRACT:

Background

Clonorchis sinensis (C. sinensis) is considered to be an important parasitic zoonosis because it infects approximately 35 million people, while approximately 15 million were distributed in China. Hepatitis B virus (HBV) infection is a major public health issue. Two types of pathogens have the potential to cause human liver disease and eventually hepatocellular carcinoma. Concurrent infection with HBV and C. sinensis is often observed in some areas where C. sinensis is endemic. However, whether C. sinensis could impact HBV infection or vice versa remains unknown.

Principal findings

Co-infection with C. sinensis and HBV develops predominantly in males. Co-infected C. sinensis and HBV patients presented weaker liver function and higher HBV DNA titers. Combination tre

SUBMITTER: Li W 

PROVIDER: S-EPMC4922651 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature