Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.

ABSTRACT: Although Notch signaling is deregulated in prostate cancer, the role of this pathway in disease development and progression is not fully understood. Here, we analyzed 2 human prostate cancer data sets and found that higher Notch signaling correlates with increased metastatic potential and worse disease survival rates. We used the Pten-null mouse prostate cancer model to investigate the function of Notch signaling in the initiation and progression of prostate cancer. Disruption of the transcription factor RBPJ in Pten-null mice revealed that endogenous canonical Notch signaling is not required for disease initiation and progression. However, augmentation of Notch activity in this model promoted both proliferation and apoptosis of prostate epithelial cells, which collectively reduced the pri

SUBMITTER: Kwon OJ 

PROVIDER: S-EPMC4922719 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature