Association between TNF-α -308 G/A polymorphism and COPD susceptibility: a meta-analysis update.

ABSTRACT:

Background and objective

The association between TNF-α -308 G/A polymorphism and COPD remains controversial due to insufficiently strict study designs and small group sizes among different studies. In the present study, a meta-analysis update which followed a stricter procedure was performed to obtain a clearer understanding of this association.

Methods

A comprehensive database search was conducted to identify the case-control studies published up to July 2015 which reported an association between the TNF-α -308 G/A polymorphism and COPD risk. Data were extracted to calculate pooled odds ratios with 95% confidence intervals under the most appropriate genetic and allelic models. Sensitivity was analyzed, and heterogeneity as well as publication bias was assessed.

Results</

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4922767 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature