Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure.

ABSTRACT:

Unlabelled

Children with congenital heart diseases have increased morbidity and mortality, despite various surgical treatments, therefore warranting better treatment strategies. Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure. hCPCs isolated from children undergoing reconstructive surgeries were divided into 3 groups based on age: neonate (1 day to 1 month), infant (1 month to 1 year), and child (1 to 5 years). Adolescent athymic rats were subjected to sham or pulmonary artery banding surgery to generate a model of right ventricular (RV) heart failure. Two weeks after surgery, hCPCs were injected in RV musculature noninvasively. Analysis of cardiac function 4 weeks post-transplant

SUBMITTER: Agarwal U 

PROVIDER: S-EPMC4922847 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature